Dr. Burns is Co-Founder, President and Chief Executive Officer of VenatoRx. He brings over 25 years of corporate and R&D experience within both major (RPR/Aventis) and specialty (ViroPharma, Protez Pharmaceuticals) pharmaceutical environments. At VenatoRx, Dr. Burns developed a comprehensive U.S. Government/NGO financing strategy that enabled the Company to build out a world-class antibacterials portfolio. Prior to VenatoRx, Dr. Burns served as a member of the Executive Management Team and as Vice President of Research at Protez Pharmaceuticals through its acquisition by Novartis in 2008. Prior to Protez/Novartis he served as Director of Chemistry at ViroPharma, producing clinical candidates for Hepatitis C (HCV-796) and smallpox infections (Tecovirimat, licensed to and developed by Siga Technologies). Prior to this, Dr. Burns served as a core member of the Global Lead Optimization Counsel at Rhone-Poulenc Rorer/Aventis. During his 12 years at RPR/Aventis, Dr. Burns led multidisciplinary teams in bone metabolism, cardiovascular disease (in the U.S.), and oncology (in France). Dr. Burns has appeared as co-author or co-inventor on more than 60 patents and publications and has served as Principal Investigator on more than 10 awarded U.S. National Institute of Health (NIH) grants. He received his Ph.D. in Organic Chemistry in 1989 from the Massachusetts Institute of Technology (MIT) under Nobel-laureate Professor K. Barry Sharpless. He currently serves on the Board of Directors at Life Sciences Pennsylvania.
Dr. Pevear is Co-Founder and Senior Vice President of Biology and Grants Development at VenatoRx Pharmaceuticals. He has over 25 years of experience in anti-infectives drug discovery and development, covering both anti-bacterials and anti-virals. He was previously the Director of Biology at Protez Pharmaceuticals (a subsidiary of Novartis Pharmaceuticals Corporation) where he co-led the team who advanced a first-in-class beta-lactamase inhibitor into preclinical development. Prior to Protez, Dr. Pevear spent two years with Novartis Pharmaceuticals in Cambridge, MA, where he directed the billion dollar collaboration with Alnylam Pharmaceuticals on ground-breaking “RNA interference” technology. He has also worked with Progenics Pharmaceuticals (Tarrytown, NY) where he directed research efforts in both Human immunodeficiency virus and Hepatitis C virus. In 1994 Dr. Pevear was a scientific team founding member of ViroPharma Inc. (Exton, PA). As the Director of Biology at ViroPharma, Dr. Pevear led a team of over 30 scientists working on a variety of anti-infective targets. He also served on the team that advanced a first-in-class inhibitor for the common cold viruses through NDA filing. This compound was discovered by Dr. Pevear’s laboratory during his time with Sterling Winthrop Research Institute (1988–1994). Dr. Pevear has been involved in the advancement of more than a dozen compounds from the lab bench into clinical development. He has published over 80 papers in peer-reviewed journals and has written more than a half dozen reviews. Dr. Pevear has served as the Principal Investigator and/or written 6 SBIR-Advanced Technology awards and contributed to several others. He also served as an NIH Center for Scientific Review Special Emphasis Panel Member for AIDS SBIR applications in 2005. He received his Ph.D. in Viral Immunology from Rensselaer Polytechnic Institute in 1984, and was a Postdoctoral Fellow of the National Multiple Sclerosis Society in the lab of Dr. Howard Lipton (Northwestern University Medical School, Chicago, IL) from 1985–1988.
Dr. Xerri is Co-Founder and Chief Development Officer of VenatoRx Pharmaceuticals. He has been co-founder and Chief Scientific Officer of Protez Pharmaceuticals and was previously Director of Antimicrobial Disease Strategy at GlaxoSmithKline. He had responsibility for the appropriate risk assessment of the portfolio, aligning discovery with Business Development, and to fill gaps via in-licensing. During his 36 year career in antibacterials, he has led or been part of international teams for the pre-clinical and clinical development of cephalosporins (cefuroxime and ceftazidime), carbapenems (Sanfetrinem and Razupenem) and quinolones (ofloxacin, levofloxacin and grepafloxacin) and made key contributions to their commercialization strategies. Dr. Xerri holds a Laurea in Biology and Microbiology from the University of Bologna, Italy.
Dr. Coburn is Director of Virology at VenatoRx Pharmaceuticals, Inc. where he currently leads antiviral drug discovery efforts focused on hepatitis B virus and other human viral pathogens. Dr. Coburn was previously Director of Biology at Progenics Pharmaceuticals, Inc. (Tarrytown, NY) where he established a small-molecule discovery group and led programs that targeted hepatitis C virus (HCV) entry. At ViroPharma, Inc. (Exton, PA), Dr. Coburn contributed to the discovery and advancement of multiple compounds into the clinic including a first-in-class, non-nucleoside inhibitor of the HCV polymerase that progressed into Phase II clinical testing. Dr. Coburn is the Principal Investigator for multiple National Institutes of Health (NIH) SBIR grant awards and has served as an NIH reviewer on numerous scientific review panels focused on antiviral drug discovery. Dr. Coburn received his Ph.D. in Biochemistry and Molecular Biology from the University of British Columbia (Vancouver, Canada) and completed post-Doctoral training in Dr. Bryan Cullen’s laboratory at Duke University (Durham, NC). As a Fellow of the Howard Hughes Medical Institute (1999-2003), Dr. Coburn made important contributions that advanced our fundamental understanding of mammalian retroviral biology.
Dr. Condon has been engaged in the discovery and development of bioactive compounds for over 20 years. Dr. Condon joined VenatoRx in 2016 as Vice President, Chemistry. Prior to joining VenatoRx, Dr. Condon served in multiple roles at TetraLogic Pharmaceuticals where he led a team of scientists in the identification and evaluation of small molecule antagonists of the Inhibitor of Apoptosis (IAP) family of proteins. Together with an international team of collaborators, scientists at TetraLogic uncovered the central role of the cellular IAP proteins in TNF signaling, inflammation, and tumor cell death that led to the discovery of birinapant, a first-in-class bivalent IAP antagonist. Prior to TetraLogic, Dr. Condon was Group Leader in Medicinal Chemistry at ViroPharma where his team invented the first HCV NS5B inhibitor to demonstrate efficacy in the humanized mouse model of HCV infection. Dr. Condon began his professional career at Rhône-Poulenc Rorer. His team at RPR determined the bioactive conformation of human parathyroid [1-34] and developed a number of anabolic peptides for the treatment of post-menopausal osteoporosis. Dr. Condon received his doctoral degree from the University of Pennsylvania following his dissertation with Professor Amos B. Smith III on the total synthesis of rapamycin and demethoxyrapamycin.
Dr. Daigle is Associate Director of Biology at VenatoRx Pharmaceuticals where he currently is the scientific lead overseeing drug discovery efforts focused on a novel next-generation antibiotic approach. Dr. Daigle heads the biochemistry sub-team responsible for detailed mechanistic evaluation of enzyme inhibitors for antibacterial targets and mechanism of action studies including construction of genetic tools in support of both drug discovery programs and advanced products for product differentiation and scientific publishing. Dr. Daigle also heads a PK/PD sub-team involved in early investigatory in vitro PK/PD models to support and guide external PK/PK studies. Dr. Daigle has been instrumental in securing funding from the Department of Defense (DTRA) and CARB-X to support ongoing drug discovery programs. Dr. Daigle received his Ph.D. in Biochemistry from McMaster University (Hamilton, Canada) and completed post-doctoral training as a Presidential fellow in Infectious Diseases at the Novartis Institutes for Biomedical Research (Cambridge MA), where he made important contributions to understanding the regulation of expression of RND drug efflux systems in P. aeruginosa.
Ezra Felker was appointed Chief Operating Officer in January of 2017 after serving as Chief Business Officer since May 2013. Mr. Felker has over 20 years of experience in biotechnology, pharmaceutical, and diagnostics, spanning business development, operations, and venture capital. Most recently, Ezra was VP, Operations at NuPathe where he was responsible for commercial manufacturing, technical operations, and new product planning. He assumed this position in May 2011 after acting as Vice President, Business Development since January 2006. Previously, Ezra served as an Entrepreneur in Residence at BioAdvance, where he advised on investment opportunities and provided assistance to portfolio companies. Prior to that, Mr. Felker served as Associate Vice President, BTG Ventures at BTG International. Ezra was the founding investor in Protez Pharmaceuticals, which was subsequently acquired by Novartis. Ezra has also served in business roles at Icagen (RTP, NC) and Athersys (Cleveland, OH). He has also worked as a protein chemist at Hybritech and Biosite Diagnostics in San Diego, CA. Ezra is an active participant in the entrepreneurial community in Philadelphia. He serves on the Investment Advisory Committee of Ben Franklin Technology Partners and advises several biotech and medical device companies in Philadelphia. Ezra holds a BS from the University of California, San Diego and an MBA from the Weatherhead School of Management at Case Western Reserve.
Brooke Geibel is Director, Clinical Research at VenatoRx Pharmaceuticals where her responsibilities include design, oversight, execution, and interpretation of results for Phase 1 clinical trials.
Brooke has a robust combination of experience in the pharmaceutical industry, beginning her career in the Investigative Toxicology Department at Merck & Co conducting in vitro characterization of hepatotoxicity.
Her experience in Clinical Research includes early and late phase development from the conduct of Phase 1-4 trials across multiple indications, to lifecycle management, product acquisition, and divestiture. Prior to joining VenatoRx, Brooke was Associate Director, Clinical Team Lead at Shire Pharmaceuticals, with responsibility for trial design, oversight, execution, and interpretation of results for Global Clinical Development Programs in both insourced and outsourced environments. Her experience spans pediatric, adolescent, and adult indications that have supported multiple product approvals in the US, Europe, and Latin America.
Brooke was recognized as Project Manager of the Year by Pharma Times in The 2015 Clinical Researcher of the Year Competition.
Dr. Henkel has spent 20 years in the biopharmaceutical industry developing antibacterial, antifungal, antiviral, immunomodulatory and oncology drugs. He has successfully developed biologics, small molecules and natural products in the US and Europe. Prior to joining VenatoRx, Dr. Henkel was Executive Vice President of Research and Development at Ceptaris Therapeutics (acquired by Actelion). Dr. Henkel was also Executive Vice President of Research and Development at Ception Therapeutics (acquired by Cephalon), Executive Vice President and Chief Medical Officer of Vicuron Pharmaceuticals (acquired by Pfizer), and Vice President of Worldwide Anti-Infective Clinical Development for SmithKline Beecham. Prior to joining SmithKline Beecham, Dr. Henkel was Assistant Professor of Internal Medicine and Infectious Diseases at Washington University in St. Louis, where he also earned his board certifications in both Internal Medicine and in Infectious Diseases. He received his M.D. degree and a Ph.D. in immunology from Washington University in St. Louis, and his B.S. in Chemistry and Biology from Rhodes College.
Heather Hunter is Vice President, Communications at VenatoRx Pharmaceuticals where she is responsible for all internal and external communications for the company. Heather is an executive-level communications, marketing and investor relations professional who has been a champion for entrepreneurs, start-ups and growth-stage companies for 20 years. She has experience working in a variety of industries including venture capital, healthcare (specialty pharmaceuticals, medical devices, diagnostics, digital health), technology (adtech, martech, fintech) and commercial real estate with public and private, early-, growth- and late-stage companies.
Heather came to VenatoRx from Safeguard Scientifics (NYSE:SFE), where she implemented integrated marketing, communications and investor relations strategies that augmented business development initiatives and fostered strategic partnership opportunities, customer wins, and M&A activity at premium valuations for 80+ companies valued at $4+ billion, in aggregate. Notable success stories include Advanced Biohealing (acquired by Shire), Alverix (acquired by Becton Dickinson), Avid Radiopharmaceuticals (acquired by Eli Lilly), Clarient (acquired by GE Healthcare), Laureate Pharma (acquired by Saints Capital), NuPathe (acquired by TEVA), Portico Systems (acquired by McKesson), Putney (acquired by Dechra) and ThingWorx (acquired by PTC).
Prior to Safeguard, Heather was Vice President of Corporate Communications at W. P. Carey Inc. (NYSE:WPC), a publicly traded real estate investment trust (REIT), where she developed and executed communications and marketing strategies for sale-leaseback transactions totaling $8+ billion, in aggregate. In addition, she managed the launch, branding and marketing for four public non-traded REITs which raised $2+ billion in equity, as well as the merger of six public non-traded REITs, which consisted of large portfolios of high-quality, net-leased properties.
Heather has been a Board Member for the Arts & Business Council (ABC) of Greater Philadelphia, Philadelphia Alliance for Capital and Technologies (PACT) and Philadelphia Photo Arts Center. She graduated from Yale with a B.A. in History and is President of the Yale Lacrosse Association. Heather was named to the Philadelphia Business Journal’s ’40 Under 40' List in 2017.
Douglas Krouse is Director, Program Management at VenatoRx Pharmaceuticals where his responsibilities include project management, operational support and integration, and contract compliance. Doug has more than 20 years of biopharma experience spanning research and development, process improvement, manufacturing, operations, and contract management. Prior to joining VenatoRx, Doug was a Senior Consultant at Latham BioPharm Group (LBG), where he provided program management expertise as well as systems integration and support to both government and commercial clients, ranging from small biotech to large pharma companies. Prior to LBG, Doug was Director of Operations and Project Management at a start-up company called VaxInnate, which focused on the development of recombinant vaccines targeting the stimulation of the innate immune system (via TRL5 activation). While at VaxInnate, Doug oversaw multiple development projects at various stages (R&D, preclinical, GMP manufacturing, phase 1/2 clinical), as well as the administration of a $118M HHS/BARDA contract for the development of novel seasonal and pandemic influenza vaccines. Doug earned his B.S. in Biology from The Pennsylvania State University and is certified as a Project Management Professional (PMP).
Terri Malone, M.T. has over 20 years of experience in the pharmaceutical and biotechnology industry. She has been a team member in the development of several products across indications, including Infectious Disease, Immunology and Ophthalmology. Prior to joining VenatoRx, Terri was a Director at Janssen, R&D, a division of Johnson & Johnson, having clinical and surgical operational responsibilities of a cell therapy treatment of dry age-related macular degeneration. Terri began her pharmaceutical career at Wyeth-Ayerst Research in 1995 as a Clinical Scientist in gastroenterology. She was also lead across a pediatric clinical program at AstraZeneca. Before making the transition to industry, Terri was a Medical Technologist in Clinical Microbiology at Lankenau Hospital in Wynnewood, PA. Terri earned her B.S.in Biology/Physiology from Penn State University. She completed her Medical Technology internship in Pathology at The Lankenau Hospital and is certified by the American Society of Clinical Pathology as a Medical Technologist (M.T.)
Dr. Meehan has been working with large public and venture backed start-up pharmaceutical companies for 25 years, including Merck, Johnson & Johnson, and TransForm Pharmaceuticals. Immediately prior to joining VenatoRx, he was Chief Operating Officer of TetraLogic Pharmaceuticals. Tony has played leadership roles across business development, corporate venture, finance, product development, and manufacturing. He has helped raise over $150MM in investment capital, and led teams responsible for the development of over 50 investigational molecules and 8 new product registrations, including GARDISIL®, RotaTeq®, and VIOXX®. Tony holds an M.B.A from the Wharton School of the University of Pennsylvania, a Ph.D. from Carnegie Mellon University and a B.S.E from the University of Pennsylvania.
Dr. Moeck is Vice President, Microbiology at VenatoRx Pharmaceuticals where he is responsible for ensuring comprehensive and timely characterization of investigational agents via clinical microbiology studies. He has spent over 15 years in antibacterial drug discovery and development, leading cross-functional teams or as a team member advancing the long-acting lipoglycopeptide oritavancin through nonclinical IND-enabling studies and Phase 1, 2 and 3 clinical studies, leading to its regulatory approval as OrbactivTM in the U.S. in 2014 and the European Union in 2015. Dr. Moeck's microbiology team also contributed to the successful regulatory filing of meropenem/vaborbactam which was approved as VabomereTM by the U.S. Food and Drug Administration (FDA) in 2017. Prior to joining VenatoRx, Dr. Moeck was Vice President, Biology at The Medicines Company (acquired by Melinta Therapeutics) and Senior Director of Biology at Targanta Therapeutics (acquired by The Medicines Company). He has published over 50 papers in peer-reviewed journals, co-authored three book chapters, and is co-inventor on four patents relating to methods of treatment of bacterial infections. He received his Ph.D. in Microbiology and Immunology from McGill University in Montreal, Quebec and conducted post-doctoral research at the University of Paris XI on iron acquisition in gram-negative bacterial pathogens as a Fellow of the Natural Sciences and Engineering Research Council of Canada and the Ministry of Foreign Affairs, France.
Jim has over 25 years’ experience as a senior financial executive in public and privately held companies in the life sciences and the media and technology industries. He has served as the Chief Financial Officer for three publicly held firms as well as a member of the Board of Directors of Biomimetic Therapeutics where he was the Chair of the Audit Committee. Jim has substantial fund raising experience and has helped to raise over $1.5 billion in financing for the companies he has served. Jim also has extensive merger and acquisition experience having led or participated in the purchase and sale of over 20 companies including both public and privately-held companies. Jim has worked with a number of venture capital firms including Canaan Partners, TL Ventures and Burrill and Company. Jim holds a Bachelor of Science in Accounting with Honors from Villanova University and is a Certified Public Accountant
Dr. Palucki is Senior Director and CMC Team Leader, Drug Development and Supply at VenatoRx Pharmaceuticals where he’s leveraging his knowledge and experience that spans the spectrum of drug discovery and development as well as product filing, launch, and commercialization. Dr. Palucki’s experience and technical knowledge include development and filing of new chemical entities as well as product value extension across various routes of administration, devices, and sterile products. Prior to joining VenatoRx, Dr. Palucki spent 20 years at Merck & Co. in various functional areas including 1) Process Research leading a group of synthetic chemists to define efficient syntheses of drug substance as well as lead cross functional teams spanning discovery and development to identify the optimal phase and formulation/vehicle for early development candidates, 2) Director and Team Leader in the Project Leadership Group wherein he led broad cross functional CMC-based integrated development and supply teams from phase III development through filing, launch and commercial supply and 3) Product Development and Portfolio Leader for mature brands, with responsibilities of identifying new and innovative product opportunities for existing brands by leading business opportunity assessment teams as well as product development implementation teams. Dr. Palucki obtained his Ph.D. in Organic Chemistry from Harvard University and was a National Institutes of Health Postdoctoral Fellow at the Massachusetts Institutes of Technology. He is an author/co-author of 43 publications and 10 patents.
Dr. Rosen joined VenatoRx in 2015 as Vice President of Pharmaceutical Product Development. In this role, he is responsible for developing and executing CMC strategies for drug substance and drug product, spanning from preclinical development to commercialization. Prior to joining VenatoRx, Dr. Rosen spent 22 years at Merck where he contributed to the development and registration of seven products approved for the treatment of Human Immunodeficiency Virus, Hepatitis C Virus, Type 2 Diabetes, cardiovascular disease and insomnia. Dr. Rosen received Ph.D. and M.A. degrees from Princeton University and B.S.E. from the University of Pennsylvania, all in Chemical Engineering. He is a member of the American Institute of Chemical Engineers and the American Association of Pharmaceutical Scientists, and currently serves on the Editorial Advisory Board of the Journal of Pharmaceutical Sciences.